NOAC Drug Interactions*
Strong CYP3A4 Inhibitors Strong CYP3A4 Inducers P-glycoprotein Inhibitors P-glycoprotein Inducers
  • Itraconazole
  • Ketoconazole
  • Voriconazole
  • Clarithromycin
  • Diltiazem
  • Verapamil
  • Quinidine
  • Amiodarone
  • Nefazodone
  • Grapefruit juice
  • All HIV protease inhibitors (eg. Ritonavir, Indinavir)
  • Imatinib
  • Conivaptan
  • Carbamazepine
  • Phenytoin
  • Fosphenytoin
  • Oxcarbazepine
  • Barbiturates
  • Rifampin
  • Rifabutin
  • St. John’s Wort
  • Efavirenz
  • Nevirapine
  • Nafcillin
  • Itraconazole
  • Ketoconazole
  • Voriconazole
  • Clarithromycin
  • Diltiazem
  • Nefazodone
  • All HIV protease inhibitors (eg. Ritonavir, Indinavir)
  • Imatinib
  • Indinavir
  • Conivaptan
  • Prazosin
  • Tipranavir
  • Trazodone
  • Vinblastine
  • Doxorubicin
*This list includes some of the drugs most likely to be encountered in the ED. Other drugs should be investigated if the clinician is uncertain about potential drug interactions.

[Schulman S et al. Blood. 2013;119:3016-3023.]